Scientists Use Dynamic Medicinal Chemistry to Help Cardiac Regeneration
San Diego, Calif. (January 16, 2012) – Scientists at the Human BioMolecular Research Institute (HBRI) in San Diego, CA, and Sanford-Burnham Medical Research Institute (Sanford-Burnham) in La Jolla, CA and ChemRegen, Inc., a San Diego for-profit company focused on developing small-molecule regenerative medicines for human diseases have reported on a new set of small molecules helpful in human cardiomyocyte formation using inhibition of a biochemical signaling pathway called Wnt. The Wnt signaling pathway is a key mediator of cellular development and stem cell differentiation. A paper published online in the Journal of Medicinal Chemistry reports a new class of small molecules that work as Wnt inhibitors that can be used to increase cardiogenesis from human stem cells.
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