Scientists Use Dynamic Medicinal Chemistry to Help Cardiac Regeneration

San Diego, Calif. (January 16, 2012) – Scientists at the Human BioMolecular Research Institute (HBRI) in San Diego, CA, and Sanford-Burnham Medical Research Institute (Sanford-Burnham) in La Jolla, CA and ChemRegen, Inc., a San Diego for-profit company focused on developing small-molecule regenerative medicines for human diseases have reported on a new set of small molecules helpful in human cardiomyocyte formation using inhibition of a biochemical signaling pathway called Wnt. The Wnt signaling pathway is a key mediator of cellular development and stem cell differentiation. A paper published online in the Journal of Medicinal Chemistry reports a new class of small molecules that work as Wnt inhibitors that can be used to increase cardiogenesis from human stem cells.

Lanier M, Schade D, Willems E, Tsuda M, Spiering S, Kalisiak J, Mercola M, and Cashman JR (2011) Wnt inhibition correlates with human embryonic stem cell cardiomyogenesis: An SAR study based on IWR-1 analogs. J Med Chem 55(2):697-708.